Key result
Cocaine at clinical plasma levels inhibits baroreceptor function and reduces baroreflex slope in animal models.
Why the study?
The mechanisms underlying blood pressure and heart rate increases during cocaine intoxication, particularly the role of peripheral actions at baroreceptor afferents, are poorly understood.
Does cocaine inhibit baroreceptor function in animal models?
Population
In vitro rat aortic arch baroreceptors and in vivo rabbit carotid sinus models
Comparison
Cocaine perfusion at varying concentrations vs baseline baroreceptor function
Design
Preclinical experimental study with in vitro and in vivo preparations
Authors
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Indicates potential peripheral mechanism for cocaine cardiotoxicity; leaves open translation to human physiology and clinical relevance.
Does cocaine inhibit baroreceptor function in animal models?
Cocaine inhibits baroreceptor function at clinically relevant concentrations, suggesting a peripheral mechanism for cocaine-induced cardiovascular complications.
Andresen et al. (1990) studied Cocaine intoxication. Cocaine was evaluated on Baroreceptor discharge and baroreflex relationship. Cocaine inhibited baroreceptor function in rat aortic arches and reduced the slope of the baroreflex relationship in rabbits at concentrations similar to clinical plasma levels.
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