October 15, 2001Genes & DevelopmentOpen Access

Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA

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Population

Cardiomyocytes (preclinical model)

Design

Preclinical

Authors

Discussion

Does not support clinical translation; leaves open whether RhoA-GATA-4 drives human cardiomyocyte hypertrophy.

Population

Cardiomyocytes (preclinical model)

Intervention

Manipulation of RhoA and GATA-4 signaling (overexpression, dominant-negative GATA-4)

Outcome

Sarcomere reorganization and transcriptional activity of GATA-4surrogate

Identifies GATA-4 as a key nuclear mediator of RhoA signaling in cardiomyocyte sarcomere reorganization and hypertrophic growth.

Charron et al. (2001) studied this question.

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