Key result
The AT1R -521CC genotype was associated with a significant reduction in diastolic blood pressure in response to telmisartan treatment compared to T allele carriers.
Why the study?
Do genetic variants of the angiotensin II type 1 receptor affect blood pressure response to telmisartan in Chinese patients with mild-to-moderate primary hypertension?
Cohort (n=148)
Single-blind
Do genetic variants of the angiotensin II type 1 receptor affect blood pressure response to telmisartan in Chinese patients with mild-to-moderate primary hypertension?
The AT1R -521CC genotype is associated with a significantly greater reduction in diastolic blood pressure in response to telmisartan in Chinese patients with mild-to-moderate hypertension.
No immediate change to telmisartan prescribing; leaves open validation in randomized pharmacogenetic trials.
The renin-angiotensin-aldosterone system plays a key role in regulating blood pressure by maintaining vascular tone and the water/sodium balance. Many antihypertensive drugs target the renin-angiotensin-aldosterone system, but the effect differs considerably among hypertensive patients. We investigated whether genetic variants of the angiotensin II type 1 receptor are associated with blood pressure response to angiotensin II receptor blockers in hypertensive Chinese patients. After a 2-week single-blind placebo run-in period, 148 patients with mild-to-moderate primary hypertension received monotherapy with 80 mg/day telmisartan and then were followed up for 8 weeks. The 1166A/C, 573T/C, -810A/T, and -521C/T polymorphisms of the AT1R gene were determined through PCR and RFLP analysis. The relationship between these polymorphisms and changes in blood pressure was observed and evaluated after 8 weeks of treatment. Patients with the AT1R -521CC genotype had a significant reduction in diastolic blood pressure compared to those carrying the T allele. No significant reduction in blood pressure was found in individuals with the 1166A/C, 573T/C, or -810A/T polymorphisms of the AT1R gene. We conclude that only the AT1R -521CC genotype is associated with a significant decrease in blood pressure in response to telmisartan treatment in Chinese hypertensive patients.
No takes yet. Share an insight, caveat, or question.
Gong et al. (2013) conducted a cohort in mild-to-moderate primary hypertension (n=148). AT1R -521CC genotype vs. T allele carriers was evaluated on reduction in diastolic blood pressure. The AT1R -521CC genotype was associated with a significant reduction in diastolic blood pressure in response to telmisartan treatment compared to T allele carriers.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: