Myosin V processivity: Multiple kinetic pathways for head-to-head coordination

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Structured PICO

Population

Single myosin V molecules

Intervention

Perturbation of processive runs by varying nucleotide content

Outcome

Mechanism of head-to-head coordination during processive runs

Myosin V head-to-head coordination involves multiple cooperative kinetic pathways rather than a single mechanism, ensuring robust processivity.

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Challenges single-mechanism models of myosin V; leaves open translation to human cardiac motor protein dynamics.

Baker et al. (2004) studied this question.

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