A Model of Myosin V Processivity

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Population

Myosin V interacting with actin

Design

Preclinical

Authors

Discussion

No immediate implications for cardiac myosin therapies; extends strain-dependent ADP release models from kinesin to myosin V on actin.

Population

Myosin V interacting with actin

Intervention

Measurement of kinetics of nucleotide release, phosphate release, and weak-to-strong transition

Outcome

Kinetics of nucleotide release, phosphate release, and weak-to-strong transition

Myosin V processivity involves rapid phosphate release upon actin encounter and strain-dependent ADP release, similar to kinesin on microtubules.

Rosenfeld et al. (2004) studied this question.

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