Population
Single isolated calcium-tolerant rabbit atrioventricular (AV) nodal cells (ovoid n=75, rod-shaped n=16)
Comparison
Whole-cell patch clamp technique for… vs Comparison between ovoid and rod-shaped cell…
Design
Preclinical
Authors
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Cellular heterogeneity identified in rabbit AV node; leaves open relevance to human conduction before clinical translation.
The study identifies at least two distinct populations of isolated rabbit AV nodal cells (ovoid and rod-shaped) with different action potentials and ionic current profiles, which may explain the complex electrophysiology of the intact AV node.
Munk et al. (1996) studied this question.
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