October 1, 1994Journal of Cardiovascular Electrophysiology

Differential Effect of Esmolol on the Fast and Slow AV Nodal Pathways in Patients with AV Nodal Reentrant Tachycardia

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Why the study?

Does intravenous esmolol differentially affect refractoriness and conduction in the fast and slow AV nodal pathways in patients with AVNRT?

Structured PICO

Does intravenous esmolol differentially affect refractoriness and conduction in the fast and slow AV nodal pathways in patients with AVNRT?

Population

13 patients with discontinuous AV nodal conduction properties and typical AV nodal reentrant tachycardia (AVNRT)

Intervention

Intravenous esmolol (500 micrograms/kg for 1 minute, 150 micrograms/kg per minute for the next 4 minutes, followed by a continuous maintenance infusion of 50 to 100 micrograms/kg per minute)

Comparator

Baseline (pre-infusion)

Outcome

Anterograde and retrograde effective refractory periods and conduction intervals (AH and HA) of the fast and slow AV nodal pathwayssurrogate

Esmolol demonstrates differential effects on the fast and slow AV nodal pathways, which may be clinically useful for demonstrating slow pathway conduction in AVNRT patients.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May facilitate slow pathway identification in AVNRT; leaves open clinical utility, requiring prospective confirmation.

Cite This Study

Philippon et al. (1994) studied this question.

synapsesocial.com/papers/6a20a37901bc09701ff370d5 https://doi.org/10.1111/j.1540-8167.1994.tb01119.x

View Full Paper

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Differential Effect of Esmolol on the Fast and Slow AV Nodal Pathways in Patients with AV Nodal Reentrant Tachycardia

Structured PICO

Discussion

Implication

Cite This Study

Differential Effect of Esmolol on the Fast and Slow AV Nodal Pathways in Patients with AV Nodal Reentrant Tachycardia

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider