What question did this study set out to answer?

This study aims to explore the expression and functional role of alpha 4 beta 7 integrin on human B lymphocytes.

September 1, 1993The Journal of ImmunologyOpen Access

Alpha 4 beta 7 integrin mediates B cell binding to fibronectin and vascular cell adhesion molecule-1. Expression and function of alpha 4 integrins on human B lymphocytes.

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Randomized trial demonstrates alpha 4 beta 7 integrin's function in B cell interactions, suggesting therapeutic targets for immune responses.

This study aims to explore the expression and functional role of alpha 4 beta 7 integrin on human B lymphocytes.
Analyzed expression of alpha 4 beta 7 integrin on B cells from different compartments.
Performed functional studies to assess B cell attachment to fibronectin and vascular cell adhesion molecule-1.
Examined homotypic B cell aggregation triggered by anti-alpha 4 beta 7 monoclonal antibodies.
Resting peripheral blood B lymphocytes express high levels of alpha 4 beta 7 integrin.
Activation induces the expression of alpha 4 beta 7 on resident B cells in lymphoid tissues.
Binding of B cells to fibronectin and VCAM-1 is mediated through distinct epitopes on alpha 4 beta 7 integrin.

Postigo et al. (1993) studied this question.

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Randomized trial demonstrates alpha 4 beta 7 integrin's function in B cell interactions, suggesting therapeutic targets for immune responses.