What question did this study set out to answer?

Review the molecular structure, bidirectional signaling capabilities, and functional roles of the integrin beta subunit in physiological processes and human disease.

March 1, 1998The International Journal of Biochemistry & Cell BiologyOpen Access

The integrin β subunit

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Authors

LGLinda J. GreenWellcome Centre for Cell-Matrix Research AMA. Paul MouldUniversity of Manchester MHMartin J. HumphriesKagoshima University

Discussion

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Implication

Scientific review highlights bidirectional signaling and ligand-binding functions of the integrin beta subunit in human cells, indicating strong potential for targeted therapeutic interventions.

Key Points

Review the molecular structure, bidirectional signaling capabilities, and functional roles of the integrin beta subunit in physiological processes and human disease.
Synthesized molecular and structural evidence regarding integrin alpha/beta heterodimers, extracellular ligand-binding regions, and cytoplasmic domains.
Assessed the involvement of integrin-mediated cell adhesion across neoplastic, inflammatory, traumatic, and infectious disease pathologies.
Characterized a distinct ligand-binding region on the beta subunit structurally homologous to domains previously identified on alpha subunits.
Identified specific amino acid sequences within beta subunit cytoplasmic tails that bind cytoskeletal proteins and intracellular signaling complexes to drive bidirectional communication.
Demonstrated that integrin adhesion mechanisms contribute directly to all four major classes of human disease, confirming their value as therapeutic targets.

Cite This Study

Green et al. (1998) studied this question.

synapsesocial.com/papers/6a6fa85935aa2c282ce0fe8b https://doi.org/10.1016/s1357-2725(97)00107-6

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Implication

Scientific review highlights bidirectional signaling and ligand-binding functions of the integrin beta subunit in human cells, indicating strong potential for targeted therapeutic interventions.

The integrin β subunit

Discussion

Member takes

Implication

Key Points

Cite This Study

The integrin β subunit

Discussion

Member takes

Implication

Key Points

Cite This Study

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