What question did this study set out to answer?

Predict the structural fold of the conserved N-terminal ligand-binding region of the integrin beta subunit to facilitate recombinant expression and direct structural determination.

January 6, 1997FEBS Letters

A structure prediction for the ligand‐binding region of the integrin β subunit: evidence for the presence of a von Willebrand factor A domain

View Full Paper

Ask AI

Bookmark

Authors

DTDanny TuckwellNovartis (Switzerland)MHMartin J. HumphriesKagoshima University

Discussion

Member takes

Implication

Computational modeling study reveals a von Willebrand factor A domain in the integrin beta subunit, suggesting a conserved structural module mediates cell adhesion.

Key Points

Predict the structural fold of the conserved N-terminal ligand-binding region of the integrin beta subunit to facilitate recombinant expression and direct structural determination.
Conducted primary, secondary, and tertiary protein structure prediction analyses on the conserved N-terminal sequence of the integrin beta subunit.
Structural prediction analyses revealed that the conserved N-terminal region folds into a von Willebrand factor A domain.
The identification places a well-characterized structural fold at the central ligand-binding site of the integrin receptor.

Cite This Study

Tuckwell et al. (1997) studied this question.

synapsesocial.com/papers/6a94d687b1b9682fb47c3fb9 https://doi.org/10.1016/s0014-5793(96)01368-3

View Full Paper

Ask AI

Bookmark

Implication

Computational modeling study reveals a von Willebrand factor A domain in the integrin beta subunit, suggesting a conserved structural module mediates cell adhesion.

A structure prediction for the ligand‐binding region of the integrin β subunit: evidence for the presence of a von Willebrand factor A domain

Discussion

Member takes

Implication

Key Points

Cite This Study

A structure prediction for the ligand‐binding region of the integrin β subunit: evidence for the presence of a von Willebrand factor A domain

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider