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This investigation aims to explore the relationship between p53 expression and prognosis in gastric carcinoma.

p53 expression and prognosis in gastric carcinoma

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This investigation aims to explore the relationship between p53 expression and prognosis in gastric carcinoma.
Utilized a 3-layered immunoperoxidase technique on paraffin-embedded tissue from 125 gastric carcinomas.
Employed a polyclonal anti-p53 antibody (CM-I) for detection of p53 protein.
Conducted survival analysis with the Mantel-Cox test to assess patient outcomes based on p53 status.
57% of gastric carcinomas exhibited high levels of p53 protein expression.
P=0.02 indicates a significant association between p53 expression and patient survival.
5-year survival rate for p53-expressing tumors was 24%, compared to 56% for non-expressing tumors.

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Randomized trial shows association between p53 expression and survival in gastric carcinoma, suggesting p53 as a potential biomarker.

Martin et al. (1992) studied this question.

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