July 1, 2012
Transapical aortic valve implantation - The Leipzig experience.
Key result
Transapical transcatheter aortic valve implantation in high-risk patients with severe aortic stenosis achieved a procedural success rate of 90.2% and a 30-day survival rate of 90%.
Population
439 high-risk patients with aortic stenosis treated at a single center, mean age 81.5±6.4 years, 64.0%…
Design
Cohort
Follow-up
5 years
Authors
Discussion
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Member takes
Implication
Supports feasibility in high-risk aortic stenosis; leaves open need for RCTs on durability and learning curve effects.
Study Design
Type
Observational (n=439)
Multicenter
No
Structured PICO
P
Population
439 high-risk patients (mean age 81.5 years, 64% female) with severe aortic stenosis undergoing transapical transcatheter aortic valve implantation, followed for up to 5 years.
I
Intervention
Transapical transcatheter aortic valve implantation (taTAVI) with an Edwards Sapien valve
O
Outcome
Procedural success, overall survival up to 5 years, and learning curve (occurrence of major complications)hard clinical
Transapical TAVI is a safe and effective procedure for high-risk patients with severe aortic stenosis, offering acceptable 5-year survival but requiring a significant learning curve of approximately 150 cases to reduce major complications.
Limitations
- Retrospective nature of the analysis
- Sparse long-term echocardiographic and clinical follow-up data
Cite This Study
Holzhey et al. (2012) conducted an observational in Severe aortic stenosis (n=439). Transapical transcatheter aortic valve implantation (taTAVI) was evaluated on Procedural success. Transapical transcatheter aortic valve implantation in high-risk patients with severe aortic stenosis achieved a procedural success rate of 90.2% and a 30-day survival rate of 90%.