Key result
Accumulation of fatigue during exhaustive exercise reduced overall heart-muscle link strength by ~45% in the quadriceps and 60% in the low back compared to the non-fatigued state.
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This editorial highlights that heart-muscle coupling degrades with fatigue, emphasizing the value of a Network Physiology approach to understanding exercise and fatigue beyond isolated variables.
Sean P. Langan (2025) conducted an editorial in Exhaustive exercise and fatigue. Exhaustive exercise vs. Non-fatigued state was evaluated on Cardio-muscle synchrony (link strength between HR and EMG frequency bands). Accumulation of fatigue during exhaustive exercise reduced overall heart-muscle link strength by ~45% in the quadriceps and 60% in the low back compared to the non-fatigued state.
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