What question did this study set out to answer?

To evaluate the translational limitations of rodent experimental models and emphasize the necessity of direct human integrative physiological investigations in biomedical research.

January 4, 2012Acta PhysiologicaOpen Access

A man is not a rat is not a mouse

View Full Paper

Ask AI

Bookmark

Design

Editorial

Authors

PBPeter BieUniversity of Southern Denmark

Discussion

Member takes

Implication

This editorial highlights the importance of human integrative physiology studies in translating findings from animal models to human applications.

Key Points

To evaluate the translational limitations of rodent experimental models and emphasize the necessity of direct human integrative physiological investigations in biomedical research.
Synthesized findings and editorial publication trends from Acta Physiologica, evaluating human physiological studies relative to animal research.
Reviewed human experimental techniques, including neck suction baroreflex assessment, bilateral femoral arterial infusions, and transcranial magnetic stimulation.
Human studies comprised approximately 33% of regular journal publications, with over 50% addressing exercise-related cardiovascular, neural, and metabolic physiology.
Human experimental trials demonstrated specific regulatory mechanisms, such as post-exercise carotid baroreflex resetting, sex-specific respiratory-cardiovascular coupling, and altered cortical excitability in focal hand dystonia.
Rodent genomic models were highlighted as insufficient on their own for understanding complex human disease, requiring direct human validation for clinical and preventive medicine.

Cite This Study

Peter Bie (2012) studied this question.

synapsesocial.com/papers/6a7c20d6c2a640f0bcdf9679 https://doi.org/10.1111/j.1748-1716.2011.02390.x

View Full Paper

Ask AI

Bookmark

Implication

This editorial highlights the importance of human integrative physiology studies in translating findings from animal models to human applications.

A man is not a rat is not a mouse

Discussion

Member takes

Implication

Key Points

Cite This Study

A man is not a rat is not a mouse

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider