Recent developments in in vitro skin-on-a-chip technology: a narrative review

Purpose: This review outlines recent advances in skin-on-a-chip (SoC) and skin-integrated multi-organ-on-a-chip (MOC) technologies, emphasizing their potential to enhance dermatological research and drug testing by mimicking human physiology.Current Concepts: SoCs integrate skin models into microfluidic systems with dynamic perfusion, thereby enabling more physiologically relevant skin responses. MOC platforms link skin models with organ models such as the liver or gut, allowing the study of systemic interactions, including drug metabolism, immune responses, and inflammation.Discussion and Conclusion: These microphysiological systems reproduce human physiology more closely than traditional models. Although technical challenges remain, ongoing development may significantly improve drug screening, disease modeling, and personalized dermatological applications.