Key result
Two-component Euler-Euler modeling shows one-component models overestimate hemodynamic flow characteristics by ~100%.
Why the study?
The study was conducted to evaluate the contribution of the cell-free layer near the vessel wall to hemodynamics in a large stenotic coronary artery and assess its relevance to interventional cardiology.
Does a two-component fluid model incorporating the cell-free layer alter hemodynamic predictions in stenotic coronary vessels compared to a one-component model?
Does a two-component fluid model incorporating the cell-free layer alter hemodynamic predictions in stenotic coronary vessels compared to a one-component model?
Incorporating cell-free layer dynamics via a two-component fluid model significantly alters hemodynamic predictions in stenotic coronary arteries, highlighting limitations of traditional one-component models.
One-component models may overestimate coronary hemodynamics; leaves open whether cell-free layer modeling improves in vivo predictions.
This mainly theoretical work is devoted to the study of the contribution of the cell-free layer (CFL) near the vessel wall to hemodynamics in a large coronary artery with stenosis to assess the relevance of CFL modeling to the needs of interventional cardiology. An Euler–Euler model considering blood as a two-component fluid with a discrete phase of erythrocytes and a liquid plasma phase was applied to a simple 2d vessel with 65% stenosis. It was found that both the CFL thickness and the local contribution of the CFL thickness to hemodynamics are inhomogeneous along the vessel. The effects of CFL on the velocity profiles, vortex formation, hematocrit, viscosity, and wall shear stresses in the area of stenosis were determined. To demonstrate the significance of CFL modeling for prognostic purposes, the same hemodynamic conditions, analyzed using a one-component model, were also considered. A comparison analysis showed that the existence of CFL resulted in a significant overestimation (up to over 100%) of the main hemodynamic characteristics of the flow obtained using the model based on the Carreau equation.
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Starodumov et al. (2023) studied Stenotic coronary vessels. Two-component Euler-Euler model (cell-free layer modeling) vs. One-component model (Carreau equation) was evaluated on Hemodynamic characteristics of the flow. Cell-free layer modeling using a two-component Euler-Euler model showed that one-component models overestimate main hemodynamic characteristics of flow by up to over 100%.
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