Key result
High-sensitivity cardiac troponin T concentrations in healthy infants showed a strong negative correlation with age (r=-0.81, p<0.001), reaching adult 99th percentile levels at approximately 1 year.
Why the study?
Despite accepted use and clearly defined cut-offs for high-sensitive cardiac troponin T in adults, uncertainty regarding reference values persists in infants.
Observational (n=78)
No
Effect estimate: r=-0.81
p-value: p=<0.001
May warrant age-specific hs-cTnT thresholds in infants; leaves open validation in larger prospective cohorts.
Cardiac troponin T determination plays a dominant role in diagnosis of myocardial pathologies. Despite generally accepted use of high-sensitive cardiac troponin T assays (hscTnT) and clearly defined cut-off limit in adults, the uncertainty persists in infants. The aim of this study was to assess plasmatic concentrations of hscTnT and describe sequential age-related dynamic changes of hscTnT in healthy infants and toddlers. Seventy-eight children (52 males/26 females) from Czech Republic aged 44 to 872 days (median, interquartile range 271; 126 to 486 days) were consecutively enrolled in the single-center, prospective observational study. Plasma concentrations of hscTnT were analyzed by the electrochemiluminescent method, age-related reference intervals were calculated using the polynominal regression model. Amongst the study population (n=78), the upper limit of hscTnT concentration defined as the 99th percentile was calculated. The 99th percentile with 95 % confidence interval at the end of 2nd, 3rd, 4th, 5th, 6th and 7th month of postnatal life were: 81 (40.6 to 63.6), 61 (36.0 to 55.3), 47 (31.9 to 48.3), 37 (28.1 to 42.3), 30 (24.7 to 37.2) and 25 (21.5 to 32.7) ng/l, respectively. Concentration of adults 99th percentile (14 ng/l) was achieved approximately at 1 year of postnatal life. Statistically significant negative correlation of hscTnT concentration with age (r=-0.81, p<0.001) was found. Significant gender differences were not found (p>0.07). The study revealed substantially increased reference intervals of hscTnT levels in infants when compared with adult population. Based on our preliminary results, the age-related interpretation of hscTnT plasmatic concentration is recommended.
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Jehlička et al. (2021) conducted an observational in Healthy infants and toddlers (n=78). Postnatal age was evaluated on Correlation of high-sensitivity cardiac troponin T concentration with age (r=-0.81, p=<0.001). High-sensitivity cardiac troponin T concentrations in healthy infants showed a strong negative correlation with age (r=-0.81, p<0.001), reaching adult 99th percentile levels at approximately 1 year.
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