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April 29, 2000Philosophical Transactions of the Royal Society B Biological SciencesOpen Access

The structural basis of muscle contraction

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Population

Myosin cross-bridge and smooth muscle actin-myosin complex

Design

Review

Authors

KHKenneth C. HolmesMassachusetts Eye and Ear InfirmaryMGMichael A. GeevesHeart Failure / Cardiomyopathy

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Implication

Refines myosin cross-bridge models in contraction; leaves open translation to cardiac therapies pending functional studies.

Structured PICO

P
Population
Myosin cross-bridge and smooth muscle actin-myosin complex

This paper reviews the structural conformations of the myosin cross-bridge and their role in the power stroke of muscle contraction.

Cite This Study

Holmes et al. (2000) studied this question.

synapsesocial.com/papers/6a20aa717cf5d95c4e72e257https://doi.org/10.1098/rstb.2000.0583
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1THE DOUBLE ARRAY OF FILAMENTS IN CROSS-STRIATED MUSCLE1957 · 645 citations
  2. 2Kinetics of the interaction of 2'(3')-O-(N-methylanthraniloyl)-ATP with myosin subfragment 1 and actomyosin subfragment 1: Characterization of two acto.cntdot.S1.cntdot.ADP complexes1991 · 135 citations
  3. 3Kinetic characterization of a cytoplasmic myosin motor domain expressed in Dictyostelium discoideum.1993 · 90 citations
  4. 4The effect of nucleotide upon a specific isomerization of actomyosin subfragment 11988 · 55 citations
  5. 5Interaction of Actin and ADP with the Head Domain of Smooth Muscle Myosin: Implications for Strain-Dependent ADP Release in Smooth Muscle1998 · 166 citations