March 22, 2001Biochemistry

Conformation of Myosin Interdomain Interactions during Contraction: Deductions from Muscle Fibers Using Polarized Fluorescence

View Full Paper

Ask AI

Bookmark

Population

Myosin cross-bridge subfragment 1 (S1) in solution and cross-bridges in muscle fibers

Design

Preclinical

Authors

TBThomas P. BurghardtMayo Clinic ACAngel R. Cruz-WalkerMayo Clinic SPSungjo ParkMayo Clinic

Discussion

Member takes

Implication

Informs cross-bridge models in contraction; leaves open translation to human cardiac function or therapies.

Structured PICO

Population

Myosin cross-bridge subfragment 1 (S1) in solution and cross-bridges in muscle fibers

Intervention

Structural modeling using structure-sensitive optical spectroscopic signals (circular dichroism, absorption, fluorescence polarization) from two extrinsic probes

Outcome

Conformation of myosin interdomain interactions and lever arm movement during contraction

This basic science study elucidates the structural changes and lever arm rotation of myosin cross-bridges during muscle contraction.

Cite This Study

Burghardt et al. (2001) studied this question.

synapsesocial.com/papers/6a76b73633def31403adf9da https://doi.org/10.1021/bi002387o

View Full Paper

Ask AI

Bookmark

Conformation of Myosin Interdomain Interactions during Contraction: Deductions from Muscle Fibers Using Polarized Fluorescence

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Conformation of Myosin Interdomain Interactions during Contraction: Deductions from Muscle Fibers Using Polarized Fluorescence

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider