Why the study?
Does atrial pacing-induced chronotropic stress alter subendocardial blood flow and contractile function in dogs with pressure-overload left ventricular hypertrophy?
Does atrial pacing-induced chronotropic stress alter subendocardial blood flow and contractile function in dogs with pressure-overload left ventricular hypertrophy?
In a canine model of pressure-overload hypertrophy, pacing-induced chronotropic stress leads to a failure of subendocardial blood flow augmentation and a corresponding deterioration in subendocardial contractile function.
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Hypothesis-generating for subendocardial vulnerability in LVH; leaves open translation to human pressure-overload disease.
Nakano et al. (1989) studied this question.
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