Key result
Isolated nonalcoholic fatty liver disease was associated with significantly higher arterial stiffness compared to controls (pulse wave velocity 7.98 vs 7.40 m/s, P < 0.05).
Why the study?
Does nonalcoholic fatty liver disease (NAFLD) increase arterial stiffness and preclinical atherosclerosis in adults aged 30-70 years?
Population
220 participants, aged between 30 and 70 years, from the GOOSE population-based cohort study.
Comparison
Nonalcoholic fatty liver disease with or without… vs Controls without NAFLD
Design
Cohort
Authors
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Should not yet change practice; leaves open whether NAFLD screening refines CV risk stratification.
Cohort (n=220)
Does nonalcoholic fatty liver disease (NAFLD) increase arterial stiffness and preclinical atherosclerosis in adults aged 30-70 years?
Absolute Event Rate: 7.98% vs 7.4%
p-value: p=< 0.05
NAFLD is independently associated with increased arterial stiffness, suggesting a direct role in early vascular damage even in the absence of metabolic syndrome.
Salvi et al. (2010) conducted a cohort in Nonalcoholic fatty liver disease (n=220). Nonalcoholic fatty liver disease (NAFLD) vs. Controls (without NAFLD) was evaluated on Carotid-femoral pulse wave velocity (PWV) (p=< 0.05). Isolated nonalcoholic fatty liver disease was associated with significantly higher arterial stiffness compared to controls (pulse wave velocity 7.98 vs 7.40 m/s, P < 0.05).
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