March 1, 1997Diabetes Care
Is Type II Diabetes Associated With an Increased Risk of Cognitive Dysfunction?: A critical review of published studies
Why the study?
Is Type II diabetes associated with an increased risk of cognitive dysfunction compared to nondiabetic controls?
Population
19 controlled studies examining subjects with type II (non-insulin-dependent) diabetes
Comparison
Type II diabetes (exposure) vs Nondiabetic control subjects
Design
Review
Authors
Discussion
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Member takes
Implication
Diabetes may link to verbal memory deficits; leaves open causality and practice change pending rigorous trials.
Structured PICO
Is Type II diabetes associated with an increased risk of cognitive dysfunction compared to nondiabetic controls?
P
Population
19 controlled studies examining subjects with type II (non-insulin-dependent) diabetes
I
Intervention
Type II diabetes (exposure)
C
Comparator
Nondiabetic control subjects
O
Outcome
Cognitive function (including verbal memory, psychomotor ability, and frontal lobe function)
Type II diabetes appears to be associated with an increased risk of cognitive dysfunction, particularly affecting verbal memory, though methodological differences across studies warrant cautious interpretation.
Limitations
- Widespread differences in methodology between the studies
- Six studies showing no differences lacked adequate statistical power to detect a medium effect size (0.5 SD)
Cite This Study
Strachan et al. (1997) studied this question.