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This study aims to explore how testicular binding affects the biological activity of human chorionic gonadotropin.

Biological Activity of Human Chorionic Gonadotropin Released from Testis Binding-Sites

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This study aims to explore how testicular binding affects the biological activity of human chorionic gonadotropin.
In vitro assessment of gonadotropin binding and activation in rat testis using (125)I-labeled hormone.
Evaluation of hormone binding, adenylate cyclase activation, and steroidogenesis stimulation post-binding.
Incubation of testis with various preparations of (125)I-gonadotropin to assess changes in binding affinity and biological activity.
(125)I-gonadotropin binding to rat testis did not impair biological properties post-incubation.
Eluted gonadotropin from testis showed significantly increased binding activity to testis and stimulation of cyclic AMP production.
Hormonally eluted preparations released more testosterone than original samples, indicating enhanced biological activity through receptor-mediated uptake.

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Randomized trial examines how testicular binding affects gonadotropin activity, indicating potential clinical significance.

Dufau et al. (1972) studied this question.

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