Key result
HIV infection was independently associated with a 0.067 mm (10.8%) greater carotid intima-media thickness and increased arterial stiffness compared to controls.
Why the study?
Does HIV infection, antiretroviral therapy, or lipodystrophy increase carotid intima-media thickness and arterial stiffness in men?
Case-Control (n=129)
Does HIV infection, antiretroviral therapy, or lipodystrophy increase carotid intima-media thickness and arterial stiffness in men?
Mean Difference: 0.067
HIV infection is independently associated with increased carotid intima-media thickness and arterial stiffness, while ART use is associated with increased femoral artery stiffness.
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May signal heightened CV risk in HIV; hypothesis-generating for ART/lipodystrophy effects, needing prospective confirmation.
Vonderen et al. (2009) conducted a case-control in HIV infection (n=129). HIV infection and ART use vs. Uninfected controls and ART-naive patients was evaluated on Carotid artery intima-media thickness (C-IMT) and arterial stiffness (MD 0.067). HIV infection was independently associated with a 0.067 mm (10.8%) greater carotid intima-media thickness and increased arterial stiffness compared to controls.
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