Key result
HIV infection was associated with 4.3% lower carotid arterial distensibility compared to uninfected participants (95% CI, -7.4% to -1.1%), with a 10.5% reduction in those with <200 CD4+ cells.
Why the study?
Is HIV infection and HAART use associated with increased carotid arterial stiffness in adults?
Cross-Sectional (n=2,789)
Yes
Is HIV infection and HAART use associated with increased carotid arterial stiffness in adults?
Effect estimate: 4.3% lower (95% CI -7.4% to -1.1%)
Advanced HIV-related immunosuppression is associated with increased carotid arterial stiffness, suggesting a mechanism for increased cardiovascular risk in this population.
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Advanced HIV immunosuppression was associated with carotid stiffness; leaves open its role in excess cerebrovascular risk.
Seaberg et al. (2010) conducted a cross-sectional in HIV infection (n=2,789). HIV infection vs. HIV-uninfected participants was evaluated on Carotid arterial distensibility (4.3% lower, 95% CI -7.4% to -1.1%). HIV infection was associated with 4.3% lower carotid arterial distensibility compared to uninfected participants (95% CI, -7.4% to -1.1%), with a 10.5% reduction in those with <200 CD4+ cells.
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