Key result
HAART is linked to ~12% higher pulse wave velocity versus HAART-naive HIV patients.
Why the study?
Does highly active antiretroviral therapy (HAART) increase arterial stiffness in normotensive HIV-infected patients?
Case-Control (n=112)
Does highly active antiretroviral therapy (HAART) increase arterial stiffness in normotensive HIV-infected patients?
Absolute Event Rate: 8.4% vs 7.5%
p-value: p=0.03
HAART in HIV-infected patients is associated with increased arterial stiffness comparable to that of untreated hypertensive patients, driven by therapy duration, cholesterol levels, and blood pressure.
May warrant stiffness monitoring in HAART-treated HIV; leaves open causal effects on outcomes.
BACKGROUND: Metabolic disorders associated with atherosclerosis and cardiovascular disease have been described in "HIV-infected" individuals. We investigated (i) whether normotensive "HIV-infected" individuals and hypertensive patients have similarities regarding their arterial elastic properties and (ii) the effect of highly active antiretroviral therapy (HAART) and metabolic factors on arterial stiffness. METHODS: In a case-control study, we compared measurements of pulse wave velocity (PWV), arterial blood pressure, and markers of metabolic profile in 56 normotensive, "HIV-infected" patients (mean age 40 +/- 13 years) to 28 age- and sex-matched newly diagnosed untreated patients with hypertension and 28 healthy individuals. RESULTS: "HIV-infected" patients had higher PWV than healthy controls but lower PWV than hypertensives (8.1 +/- 1.4 m/s vs. 6.7 +/- 1.1 m/s vs. 9.0 +/- 1.0 m/s, P = 0.003 and 0.01, respectively). However, patients on HAART had similar PWV with hypertensives (8.4 +/- 1.4 vs. 9.0 +/- 1.0 m/s P = 0.25). Patients on HAART had higher PWV than patients without (8.4 +/- 1.4 m/s vs. 7.5 +/- 1.3 m/s, P = 0.03). Patients on HAART had higher total cholesterol, triglycerides, and diastolic blood pressure than patients naive to HAART (P < 0.05). In multivariate analysis, the independent determinants of increased PWV were HAART duration (unstandardized coefficient b v = 0.007, P = 0.04), serum cholesterol (b = 0.007, P = 0.04), mean or diastolic blood pressure (b = 0.049 and b = 0.060, P < 0.01). CONCLUSIONS: "HIV-infected" individuals have increased arterial stiffness compared to healthy controls. Patients on antiretroviral therapy have similarities regarding their arterial elastic properties with patients with untreated hypertension. There is an independent association between duration of antiretroviral therapy, cholesterol levels, and blood pressure with increased arterial stiffness in "HIV-infected" patients.
No takes yet. Share an insight, caveat, or question.
Lekakis et al. (2009) conducted a case-control in HIV infection (n=112). Highly active antiretroviral therapy (HAART) vs. No HAART was evaluated on Pulse wave velocity (PWV) (p=0.03). Highly active antiretroviral therapy in HIV-infected patients was associated with increased arterial stiffness, with pulse wave velocity higher than in HAART-naive patients (8.4 vs 7.5 m/s, P=0.03).