Key result
A ToV-PLP knockout mutant enterovirus showed impaired growth and induced higher expression levels of innate immune genes in infected cells compared to the wild-type virus.
Population
Novel enterovirus isolated from a diagnostic sample from a neonatal pig diarrhea case, and infected host cells
Comparison
ToV-PLP knockout recombinant virus generated… vs Wild-type virus (EVG 08/NC_USA/2015)
Design
Preclinical
Authors
Loading...
Hypothesis-generating for PLP-mediated immune evasion in enteroviruses; leaves open relevance to human disease and antiviral targets.
A naturally occurring cross-order recombination event between enterovirus G and torovirus resulted in the acquisition of a deubiquitinase that suppresses host innate immune responses, potentially improving viral fitness.
Shang et al. (2017) studied Neonatal pig diarrhea. ToV-PLP knockout recombinant virus vs. Wild-type virus was evaluated on Viral growth and innate immune gene expression. A ToV-PLP knockout mutant enterovirus showed impaired growth and induced higher expression levels of innate immune genes in infected cells compared to the wild-type virus.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: