Why the study?
Does intermittent social isolation alter the cardiovascular responses to repetitive acoustic startle stimuli in male Wistar rats?
Population
10 male Wistar rats implanted with a blood pressure (BP) telemetric system
Comparison
Intermittent social isolation for an 8 day… vs Housed in pairs for an 8 day period followed by…
Design
Preclinical, randomized cross-over study design
Follow-up
8 day period per condition
Authors
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Does not support clinical practice changes; hypothesis-generating for social isolation effects on human cardiovascular reactivity.
Does intermittent social isolation alter the cardiovascular responses to repetitive acoustic startle stimuli in male Wistar rats?
Social isolation in rats markedly alters the habituation profile of blood pressure and heart rate to repetitive alerting stimuli, potentially unmasking a tachycardic response.
Blanc et al. (1997) studied this question.
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