Why the study?
Does heart failure exacerbation increase the response to warfarin?
Population
Patients with decompensated heart failure taking warfarin or other vitamin K antagonists
Design
Review
Key result
Heart failure exacerbations may be associated with an increased response to warfarin, though evidence is limited by small patient populations and inadequate reports.
Authors
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May warrant cautious INR monitoring in decompensated HF; leaves open confirmation via prospective studies.
Does heart failure exacerbation increase the response to warfarin?
Heart failure exacerbations may increase patient sensitivity to warfarin, suggesting a need for lower starting doses and more frequent INR monitoring during periods of instability.
Self et al. (2006) conducted a review in Decompensated heart failure. Heart failure exacerbation was evaluated on Response to warfarin. Heart failure exacerbations may be associated with an increased response to warfarin, though evidence is limited by small patient populations and inadequate reports.