Key result
Surgical ASD closure linked to ~40 ms lower SDNN decades after repair vs healthy controls.
Why the study?
Patients with a corrected ASD have higher morbidity and mortality, which may be partly explained by abnormal autonomic cardiac regulation.
Does prior surgical or percutaneous closure of an atrial septal defect impact long-term heart rate variability in adulthood compared to healthy controls?
Observational (n=53)
No
Does prior surgical or percutaneous closure of an atrial septal defect impact long-term heart rate variability in adulthood compared to healthy controls?
Answers are grounded in this paper and cite their sources.
Adults with surgically or percutaneously repaired ASDs exhibit persistent sympathovagal imbalance and impaired heart rate variability decades after closure, indicating potential long-term autonomic dysregulation.
OBJECTIVES: Recent evidence suggests that patients with a corrected atrial septal defect (ASD) have higher morbidity and mortality. An abnormal autonomic regulation of the heart may be a part of the explanation for this. Our objective was to study heart rate variability (HRV) in adults with a corrected ASD as a prominent tool to investigate the autonomic regulation of the heart. METHODS: Autonomic cardiac function was investigated in adults with either a surgically closed or percutaneously closed ASD and healthy control subjects. A 48-h Holter monitor was performed on each participant and HRV was assessed. RESULTS: A total of 17 patients with surgically closed ASDs, 18 percutaneously closed ASDs and 18 controls were included. The mean age in the surgical group, percutaneous group and controls was 32 ± 9, 28 ± 7 and 32 ± 10 years, respectively. The mean time since closure was 19 ± 8 years for the surgical group and 15 ± 5 years for the percutaneous group. The surgically closed ASD patients showed decreased HRV in all six parameters studied when compared to the controls. Similarly, the percutaneously closed ASDs showed decreased HRV in three out of six parameters when compared to controls. CONCLUSIONS: Adults with an ASD, whether closed surgically or percutaneously, have impaired HRV compared to their age- and sex-matched controls, more so in the patients with a surgically closed ASD. CLINICAL TRIAL REGISTRATION NUMBER: ClinicalTrials.gov (identifier: NCT03565471).
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Alstrup et al. (2021) conducted an observational in Corrected atrial septal defect (ASD) (n=53). Surgically or percutaneously closed atrial septal defect vs. Healthy age- and sex-matched controls was evaluated on Heart rate variability assessed by SDNN (standard deviation of all time intervals between normal R peaks) (p=0.0070). Surgically closed atrial septal defects were associated with significantly impaired heart rate variability (SDNN 151 ms vs 191 ms, p=0.0070) decades after closure compared to healthy controls.
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