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What are the main risk factors associated with transient ischemic attacks in a middle-aged population?
What are the main risk factors associated with transient ischemic attacks in a middle-aged population?
In a middle-aged Italian population, female sex and the presence of cardiopathy, hypertension, diabetes, or prior heart attack were significant risk factors for transient ischemic attacks.
Cardiopathy and female sex may raise TIA risk in middle-aged adults; hypothesis-generating and requires prospective validation before guiding prevention.
A case-control study was based on "unselected" transient ischemic attacks (TIAs) in a middle-aged Italian population. The identified cases included 52 prevalent and 25 incident TIAs. There was an incidence rate ratio (female/male) of 1.8 for definite cases. Comparison with the whole population for medical history of hypertension, diabetes and heart attack showed age/sex-adjusted odds ratios of 4.3, 2.1, 7.9 for incident cases. The results were similar when a more detailed investigation of risk factors was performed with all the cases and a random sample of the controls. Moreover, female sex had an odds ratio for incident cases of 3.3 (95% confidence interval 1.0-11.3) after adjustment for age and presence of all the main risk factors. The presence of at least one cardiopathy showed an odds ratio of 8.3 for incident cases (95% confidence interval 2.4-28.4).
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Fratiglioni et al. (1991) studied this question.
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