Inactivation of cap-binding proteins accompanies the shut-off of host protein synthesis by poliovirus.
Population
HeLa cells
Comparison
Poliovirus infection vs Mock infection
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Suggests mechanism of poliovirus host shutoff; leaves open in vivo relevance and extension to other viruses.
Structured PICO
P
Population
HeLa cells
I
Intervention
Poliovirus infection
C
Comparator
Mock infection
O
Outcome
Crosslinking ability of cap-binding proteins to the 5' cap structure of oxidized reovirus mRNAsurrogate
Poliovirus infection shuts off host protein synthesis by inactivating cap-binding proteins required for the translation of capped cellular mRNAs.
Cite This Study
Lee et al. (1982) studied this question.