Key result
Cold pressor test hyper-reactors show no difference in baseline vascular stiffness compared to normo-reactors.
Why the study?
Cardiovascular hyperactivity during the cold pressor test may indicate future hypertension development, but the underlying vascular stiffness in hyper-reactors compared with normo-reactors remains to be evaluated.
Do healthy young male cold pressor test hyper-reactors have different baseline vascular stiffness compared to normo-reactors?
Cross-Sectional (n=34)
No
Do healthy young male cold pressor test hyper-reactors have different baseline vascular stiffness compared to normo-reactors?
Absolute Event Rate: 3.5% vs 3.5%
p-value: p=NS
Baseline vascular stiffness does not differ between healthy young male cold pressor test hyper-reactors and normo-reactors, suggesting that exaggerated blood pressure responses to cold stress are not driven by pre-existing differences in resting vascular tone.
Cold pressor hyper-reactivity appears independent of baseline stiffness in young males; hypothesis-generating and should not yet change practice.
Background: The cold pressor test (CPT) is a sympathoexcitatory manoeuvre to measure cardiovascular hyperactivity which may be a sign of future hypertension development. Aims and Objectives: To evaluate the vascular stiffness background among healthy CPT hyper-reactor (H-R) males and age and gender-matched normo-reactors (N-R). Methods: The study was carried out in 34 healthy young males aged 19 years old. Five minutes of recordings of left middle fingertip digital pulse wave (DPW) signals (through a piezoelectric finger pulse transducer) were registered. This was followed by the application of a cold pressor. Blood pressure (BP) and heart rate (HR) during CPT were recorded, and the individuals were divided into N-Rs and H-Rs. Vascular stiffness indices like pulse wave velocity (PWV), B/A wave ratio, pulse rising time (PRT, or crest), large artery stiffness index (SI), and pulse width (PW) were compared between H-Rs and N-Rs. Results: No significant differences were observed between the two groups across all studied parameters. Conclusion: The results suggest there was no difference in the vascular stiffness background between CPT H-R and N-R individuals.
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Adnan et al. (2023) conducted a cross-sectional in Healthy (n=34). Cold pressor test hyper-reactivity vs. Normo-reactors was evaluated on Pulse wave velocity (PWV) (p=NS). There were no significant differences in baseline vascular stiffness indices, including pulse wave velocity, between cold pressor test hyper-reactors and normo-reactors.
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