Key result
Maximal rate of systolic distension and maximal rate of diastolic recoil measured by functional MRI are significantly inversely correlated with aortic size index (r2=0.29, P≤0.0001 and r2=0.25, P=0.0003), indicating increased stiffness of the ascending aorta as it dilates.
Why the study?
To evaluate aortic wall elasticity using MRSD and MRDR and determine their correlation with the aortic size index.
Do functional MRI indexes of aortic wall elasticity (MRSD and MRDR) correlate with aortic size index and age in patients with ascending aortic aneurysm?
Observational (n=48)
No
Do functional MRI indexes of aortic wall elasticity (MRSD and MRDR) correlate with aortic size index and age in patients with ascending aortic aneurysm?
Effect estimate: r2=0.29
p-value: p=≤0.0001
Functional MRI-derived indexes of aortic wall elasticity (MRSD and MRDR) correlate significantly with aortic size index and age, providing a non-invasive method to assess aortic stiffness and potential risk in aneurysm patients.
MRI indexes may aid non-invasive stiffness assessment in aneurysms; leaves open prognostic value and clinical utility.
Objective: To evaluate the aortic wall elasticity using the maximal rate of systolic distension (MRSD) and maximal rate of diastolic recoil (MRDR) and their correlation with the aortic size index (ASI). Methods: Forty-eight patients with thoracic aortic aneurysm were enrolled in this study. A standard magnetic resonance imaging (MRI) protocol was used to calculate MRSD and MRDR. Both MRSD and MRDR were expressed as percentile of maximal area/10-3 sec. ASI (maximal aortic diameter/body surface area) was calculated. A correlation between MRSD, MRDR, ASI, and the patient’s age was performed using regression plot. Results: A significant correlation between MRSD (t=-4,36; r2=0.29; P≤0.0001), MRDR (t=3.92; r2=0.25; P=0.0003), and ASI (25±4.33 mm/m2; range 15,48-35,14 mm/m2) is observed. As ASI increases, aortic MRSD and MRDR decrease. Such inverse correlation between MRSD, MRDR, and ASI indicates increased stiffness of the ascending aorta. A significant correlation between the patient’s age and the decrease in MRSD and MRDR is observed. Conclusion: MRSD and MRDR are significantly correlated with ASI and the patient’s age. They seem to describe properly the increasing stiffness of aortas. These two new indexes provide a promising, accessible, and reproducible approach to evaluate the biomechanical property of the aorta.
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Tiwari et al. (2019) conducted an observational in Thoracic aortic aneurysm or ectasia (n=48). Aortic Size Index (ASI) was evaluated on Correlation between maximal rate of systolic distension (MRSD) and aortic size index (ASI) (r2=0.29, p=≤0.0001). Maximal rate of systolic distension and maximal rate of diastolic recoil measured by functional MRI are significantly inversely correlated with aortic size index (r2=0.29, P≤0.0001 and r2=0.25, P=0.0003), indicating increased stiffness of the ascending aorta as it dilates.
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