Key result
Creation of complete atrioventricular block in dogs significantly increased LV mass, RV mass, ejection fraction, and Q-T time within 14-21 days (all P<0.05).
Why the study?
What is the nature and time course of biventricular hypertrophy and electrical/mechanical changes after creation of complete atrioventricular block in adult dogs?
Population
6 adult dogs (22-30 kg)
Comparison
Creation of complete atrioventricular block (CAVB) vs Baseline (before CAVB creation)
Design
Preclinical
Follow-up
3 weeks
Authors
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Should not change human AV block management; leaves open time course of bradycardia-induced remodeling for translational studies.
What is the nature and time course of biventricular hypertrophy and electrical/mechanical changes after creation of complete atrioventricular block in adult dogs?
p-value: p=<0.05
In a canine model of complete AV block, electrophysiological, mechanical, and structural adaptations to bradycardia-induced volume overload develop rapidly and are completed within 3 weeks, with greater hypertrophy observed in the right ventricle.
Verduyn et al. (2001) studied Complete atrioventricular block (n=6). Creation of complete atrioventricular block (CAVB) vs. Baseline (before CAVB) was evaluated on Left ventricular mass, right ventricular mass, ejection fraction, and Q-T time (p=<0.05). Creation of complete atrioventricular block in dogs significantly increased LV mass, RV mass, ejection fraction, and Q-T time within 14-21 days (all P<0.05).
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