Magnitude of Systolic Blood Pressure Reduction and Early Achieved Blood Pressure and Clinical Outcomes After Acute Ischemic Stroke

Figures

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  Figure 1. Association of magnitude of SBP reduction and early achieved SBP with the primary outcome of death or major disability. Odds ratios and 95% CIs derived from restricted cubic spline regression, with knots placed at the 5th, 50th, and 95th percentiles of the distribution of SBP reduction and achieved SBP. The reference points were 0 for SBP reduction and 160 mm Hg for achieved SBP. Odds ratios were adjusted for age, sex, SBP at entry, randomized treatment, time from onset to randomization, current smoking, alcohol drinking, admission National Institutes of Health Stroke Scale score, premorbid use of antihypertensive medications, subtype of ischemic stroke, history of hypertension and diabetes. The primary outcome was a combination of death (modified Rankin Scale score 6) and major disability (modified Rankin Scale score 3–5). Panel A: SBP reduction within 24 hours (P for linearity=0.006); Panel B: achieved SBP at day 7 (P for linearity=0.007). NIHSS indicates National Institutes of Health Stroke Scale; OR, odds ratio; and SBP, systolic blood pressure.

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  Figure 2. Risk of primary outcome of death or major disability according to systolic blood pressure reduction and achieved systolic blood pressure in subgroups by randomized treatment. Odds ratios were adjusted for age, sex, systolic blood pressure at entry, time from onset to randomization, current smoking, alcohol drinking, admission National Institutes of Health Stroke Scale score, premorbid use of antihypertensive medications, subtype of ischemic stroke, history of hypertension and diabetes. The primary outcome was a combination of death (modified Rankin Scale score 6) and major disability (modified Rankin Scale score 3–5). NIHSS indicates National Institutes of Health Stroke Scale; OR, odds ratio; and SBP, systolic blood pressure.