Key result
Planned meta-analysis evaluates HRV as a potential biomarker for acute and chronic pain.
Why the study?
The understanding of the heart rate variability-pain nexus remains rudimentary, limiting the integration of heart rate variability as a standard pain biomarker for nonverbal patients.
Does heart rate variability correlate with experimentally induced pain and chronic pain compared to healthy controls?
Population
Individuals with experimentally induced pain and chronic pain patients compared to healthy individuals
Comparison
Chronic pain patients vs healthy individuals and HRV during experimentally induced pain
Design
Protocol for a systematic review and meta-analysis
Authors
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No practice change for pain assessment; protocol will systematically test HRV correlation with acute and chronic pain.
Meta-Analysis
Does heart rate variability correlate with experimentally induced pain and chronic pain compared to healthy controls?
This protocol outlines a planned systematic review and meta-analysis to evaluate heart rate variability as a potential biomarker for acute and chronic pain, which could aid in assessing pain in nonverbal patients.
Kildal et al. (2023) conducted a meta-analysis in Pain (acute and chronic). Pain (experimentally induced or chronic) vs. No pain or healthy controls was evaluated on Heart rate variability (vagally-mediated and indirect baroreflex-mediated measures). Heart rate variability will be evaluated as a potential biomarker for acute and chronic pain in this planned systematic review and meta-analysis protocol, which currently reports no clinical results.
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