Key result
Simulation of atrial fibrillation remodeling in aging human atrial cardiomyocyte models predicted shortened action potential duration, reduced calcium transient amplitude, and increased arrhythmia risk.
Why the study?
AF is a widespread heart disease whose prevalence increases essentially in the elderly.
Does chronic atrial fibrillation remodeling combined with aging affect action potential and calcium transient morphology in human atrial cardiomyocyte models?
Does chronic atrial fibrillation remodeling combined with aging affect action potential and calcium transient morphology in human atrial cardiomyocyte models?
Computational modeling demonstrates that age-related electrophysiological changes combined with chronic AF remodeling increase the risk of sustained arrhythmia in elderly atrial cardiomyocyte models.
Suggests heightened arrhythmia risk in elderly AF; hypothesis-generating and requires human validation before clinical relevance.
Atrial fibrillation (AF) is a widespread heart disease which prevalence increases essentially in the elderly. In this study, we combined age-related changes in cardiomyocytes electrophysiology with the effects of chronic atrial fibrillation on the population of human atrial cell models. Our age-dependent populations of models are able to reproduce experimentally observed effects of aging on action potential (AP) and calcium transient (CaT) morphology. Simulation of AF remodeling in aging models allowed us to reproduce specific shortening of AP duration on a 90% level, an increase in AP plateau, and a reduction in CaT amplitude. Our modeling results predict the increased risk of sustained arrhythmia in the elderly group of models.
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Nesterova et al. (2020) studied Atrial fibrillation. Chronic atrial fibrillation remodeling and aging was evaluated on Action potential and calcium transient morphology, and risk of sustained arrhythmia. Simulation of atrial fibrillation remodeling in aging human atrial cardiomyocyte models predicted shortened action potential duration, reduced calcium transient amplitude, and increased arrhythmia risk.
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