Key result
Increasing age and frailty index scores in mice were strongly correlated with prolonged P wave duration, reduced atrial conduction velocity, increased interstitial fibrosis, and longer-lasting atrial fibrillation.
Why the study?
Does aging and frailty increase susceptibility to atrial arrhythmias and structural remodeling in a mouse model?
Population
190 male C57BL/6 mice, including young (13.1 ± 3.0 weeks; n=80) and aged (101.8 ± 10.1 weeks; n=110) mice.
Comparison
Aging and frailty vs Young mice and mice with lower frailty index…
Design
Preclinical, Individuals performing functional measurements did not know the…
Authors
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Caution against clinical translation; leaves open frailty-targeted AF prevention trials in humans.
Does aging and frailty increase susceptibility to atrial arrhythmias and structural remodeling in a mouse model?
Absolute Event Rate: 0.25% vs 0.11%
p-value: p=<0.001
Aging and frailty in mice are associated with structural and functional atrial remodeling that creates a substrate for atrial arrhythmias, highlighting frailty as a key determinant of AF susceptibility independent of chronological age.
Jansen et al. (2017) studied Atrial Fibrillation and Aging (n=190). Aging and Frailty vs. Young age / Low frailty was evaluated on Frailty Index (FI) score (p=<0.001). Increasing age and frailty index scores in mice were strongly correlated with prolonged P wave duration, reduced atrial conduction velocity, increased interstitial fibrosis, and longer-lasting atrial fibrillation.
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