Key result
Altered activity and concentration of matrix metalloproteinases, particularly MMP-9 and MMP-2, are associated with the pathogenesis of hypertension-mediated vascular, cardiac, and renal remodeling.
Why the study?
The study aimed to review evidence on the role of matrix metalloproteinases in the development of hypertension-mediated vascular, cardiac, and renal damage.
Do changes in matrix metalloproteinase (MMP) activity contribute to the development of vascular, cardiac, and renal damage in hypertensive patients?
Do changes in matrix metalloproteinase (MMP) activity contribute to the development of vascular, cardiac, and renal damage in hypertensive patients?
MMPs may serve as valuable biomarkers for stratifying risk and potentially act as pharmacological targets to prevent progression of hypertension-mediated target organ damage.
Matrix metalloproteinases (MMPs) are important extracellular enzymes involved in many physiological and pathological processes. Changes in the activity and concentration of specific MMPs, as well as the unbalance with their inhibitors (tissue inhibitors of metalloproteinases - TIMPs), have been described as a part of the pathogenic cascade promoted by arterial hypertension. MMPs are able to degrade various protein substrates in the extracellular matrix, to influence endothelial cells function, vascular smooth muscle cells migration, proliferation and contraction, and to stimulate cardiomyocytes changes. All these processes can be activated by chronically elevated blood pressure values. Animal and human studies demonstrated the key function of MMPs in the pathogenesis of hypertension-mediated vascular, cardiac, and renal damage, besides age and blood pressure values. Thus, the role of MMPs as biomarkers of hypertension-mediated organ damage and potential pharmacological treatment targets to prevent further cardiovascular and renal complications in hypertensive population is increasingly supported. In this review, we aimed to describe the main scientific evidence about the behavior of MMPs in the development of vascular, cardiac, and renal damage in hypertensive patients.
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Bisogni et al. (2020) conducted a review in Hypertension-Mediated Organ Damage. Matrix metalloproteinases (MMPs) vs. Normal MMP levels was evaluated. Altered activity and concentration of matrix metalloproteinases, particularly MMP-9 and MMP-2, are associated with the pathogenesis of hypertension-mediated vascular, cardiac, and renal remodeling.
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