Key result
The AG genotype of the SCN5A H558R polymorphism was significantly more frequent in patients with atrioventricular block (61.2%) than in healthy controls (34.8%, p<0.0001).
Why the study?
Is the H558R polymorphism of the SCN5A gene associated with idiopathic cardiac conduction disorders?
Case-Control
Is the H558R polymorphism of the SCN5A gene associated with idiopathic cardiac conduction disorders?
Absolute Event Rate: 61.2% vs 34.8%
p-value: p=<0.0001
The AG genotype of the H558R polymorphism of the SCN5A gene is a genetic predictor of idiopathic atrioventricular and intraventricular conduction disorders.
Supports SCN5A H558R as candidate variant in idiopathic AV block; leaves open validation before any clinical testing.
AIM: The aim of this study was to investigate the predictive value of the rs1805124 polymorphism of the SCN5A gene with regard to idiopathic cardiac conduction disorders. RESULTS: The AG genotype frequency was significantly higher in patients with an atrioventricular block (61,2%±6,0%) compared with healthy control subjects (34,8%±2,3%), p<0.0001. The AG genotype frequencies among patients with only idiopathic complete right bundle-branch block (CRBBB) (54,2%±5,5%) and those with both CLBBB and LAH (50%±5,1) were significantly higher than in the control group (34,8%±2,3%), p<0.005. CONCLUSIONS: The AG genotype of the H558R (rs1805124) polymorphism of the SCN5A gene is a genetic predictor of idiopathic disorders of atrioventricular and intraventricular conduction.
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Nikulinа et al. (2015) conducted a case-control in Idiopathic cardiac conduction disorders. H558R (rs1805124) polymorphism of the SCN5A gene vs. Healthy control subjects was evaluated on AG genotype frequency (p=<0.0001). The AG genotype of the SCN5A H558R polymorphism was significantly more frequent in patients with atrioventricular block (61.2%) than in healthy controls (34.8%, p<0.0001).
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