Poor medication adherence among hospitalized heart failure patients was associated with a 70% increased risk of rehospitalization (RR 1.7) compared to good adherence.
Cohort (n=459)
No
Does good medication adherence improve survival and reduce rehospitalization in hospitalized heart failure patients?
Poor medication adherence is highly prevalent among heart failure patients in this resource-limited setting and is strongly associated with increased risks of rehospitalization and early mortality.
Relative Risk: 1.7 (95% CI 1.2–2.9)
Absolute Event Rate: 57.5% vs 43.5%
p-value: p=0.04
Abstract Objective : Management of heart failure is complex and multifaceted but adherence to medications remains the cornerstone of preventing avoidable readmissions, premature deaths, and unnecessary healthcare expenses. Despite of evidence-based efficacy on anti-failure drugs, poor adherence is pervasive and remains a significant barrier to improving clinical outcomes in heart failure population. Results : We enrolled 459 patients with established diagnosis of heart failure. The mean age was 46.4 years and participants aged ≤50 years constituted 55.4% of the cohort. There was a female predominance (56.5%), 67.5% resided in urban areas and 74.2% had primary education. Of the 419 participants eligible for assessment of medication adherence, 313 (74.7%) had poor adherence and 106 (25.3%) had good adherence. Possession of a health insurance was found to be the strongest associated factor for adherence (OR 8.7, 95% CI 4.7-16.0, P <0.001). Participants with poor adherence displayed a 70% increased risk for rehospitalization compared to their counterparts with good adherence (RR 1.7, 95% CI 1.2-2.9, p = 0.04). Poor adherence was found to be the strongest predictor of early mortality (HR 2.5, 95% CI 1.3-4.6, p<0.01). Poor medication adherence in patients with heart failure is associated with increased readmissions and mortality.
Pallangyo et al. (Tue,) conducted a cohort in Heart failure (n=459). Poor medication adherence vs. Good medication adherence was evaluated on Rehospitalization (RR 1.7, 95% CI 1.2-2.9, p=0.04). Poor medication adherence among hospitalized heart failure patients was associated with a 70% increased risk of rehospitalization (RR 1.7) compared to good adherence.