Key result
Among patients with type-1 diabetes, 62.5% were found to be at risk of developing depression, which was associated with glycemic non-control and the presence of comorbidities.
Why the study?
Given high diabetes mellitus incidence in Saudi Arabia and susceptibility to depression, the study aimed to establish the relationship between type-1 diabetes mellitus, depression, and depression risk.
Cross-Sectional (n=365)
No
A high proportion of Saudi patients with type-1 diabetes are at risk for depression, highlighting the need for routine screening, especially in those with poor glycemic control or comorbidities.
May support screening for depression in T1D with poor control or comorbidities; hypothesis-generating and requires prospective validation.
BACKGROUND AND AIMS: The importance of screening type-1 diabetic patients in Saudi Arabia is related to a high incidence rate of diabetes mellitus (DM) and the susceptibility to developing depression during or after the diagnosis. The objectives of the present study were to establish the relationship between type-1 diabetes mellitus (T1DM), depression, and depression risk among Saudi patients; estimating the prevalence and examining the relationship of depression with duration of diagnosis, the effect of glycemic control, and the presence of comorbidities. METHODS: For this observational retrospective chart review, an analytical tool was used. The population of our study comprised Saudi patients with T1DM at King Khaled University Hospital, Riyadh. Data were collected from the hospital's electronic medical records. A depression screening tool (Patient Health Questionnaire "PHQ-9") was used to measure the depression risk of the diabetic patients, who had not been assessed before. The SPSS program was used to analyze the data. RESULTS: The present study included 167 males (~45.75%) and 198 females (~54.25%). Patients with a normal body mass index (BMI) constituted 52%, while 21% were underweight, 19% were overweight, and 9% were obese. The investigators randomly selected 120 patients from the total of 365, and called them to assess their risk of developing depression. The results of the depression assessment were as follows: positive, 17 patients out of 22 (77.27%); negative, five patients out of 22 (22.73%). In total, 75 out of 120 (62.50%) patients were at risk of developing depression, while 45 patients out of 120 (37.50%) were not at risk of depression. There was a relationship between glycemic non-control, comorbidities with depression, and risk of developing depression in DM. The presence of complications was associated with diabetic and depressed patients, and the risk of developing depression may be increased with T1DM. CONCLUSIONS: To overcome the negative consequences of undiagnosed depression, screening for depression is recommended for patients with T1DM who have multiple comorbidities, glycemic non-control, diabetic complications, and unfavorable lifestyles, as well as those undergoing combination therapy with metformin.
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Aldossari et al. (2023) conducted a cross-sectional in Type-1 Diabetes Mellitus (n=365). Type-1 Diabetes Mellitus was evaluated on Risk of developing depression (assessed via PHQ-9). Among patients with type-1 diabetes, 62.5% were found to be at risk of developing depression, which was associated with glycemic non-control and the presence of comorbidities.
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