Key result
A 12-week after-school physical activity program significantly reduced C-reactive protein by 27.7% and improved lipid profiles and VO2peak in male children with overweight or obesity.
Why the study?
Childhood or adolescent overweight and obesity cause arterial endothelial dysfunction in adulthood, prompting investigation into the effects of after-school physical activity on VO2peak, CRP, miR-125a-5p, and lipid profiles.
Does a 12-week after-school physical activity program improve VO2peak, CRP, miR-125a-5p, and lipid profiles in male children with overweight/obesity?
RCT (n=24)
Stratified randomization
No
Does a 12-week after-school physical activity program improve VO2peak, CRP, miR-125a-5p, and lipid profiles in male children with overweight/obesity?
Absolute Event Rate: -27.7% vs 9.7%
p-value: p=0.001
A 12-week after-school physical activity program significantly improves endothelial function biomarkers, lipid profiles, and aerobic capacity in adolescent boys with overweight or obesity.
Supports after-school activity programs for overweight boys; extends RCT evidence on pediatric CRP and lipid improvements.
Background: One of the causes of arterial endothelial dysfunction in adulthood is obesity or overweight in childhood or adolescence. Objectives: This study aimed to investigate the effect of a selected after-school physical activity protocol on peak oxygen consumption (VO2peak), C-reactive protein (CRP), miR-125a-5p level, and lipid profile of male children with overweight/obesity. Methods: Twenty-four boy children with overweight/obesity (aged 13 - 15 years) were assigned to after-school physical activity (APA, BMI = 27.5±1.4 kg/m2, n = 12) and control (CON, BMI = 26.28 ± 2.3 kg/m2, n = 12) groups. The APA participants took part in exercise intervention for 12 weeks, three sessions per week. Changes in VO2peak, CRP, miR-125a-5p, and lipid profile of participants were assessed before and after exercise interventions. Results: There were significant reductions in CRP (-27.7% vs. 9.7%), miR-125a-5p (36.7% vs. 7.6%), fat percentage (-8.24% vs. 0.7%), LDL (-17.66% vs. 1.9%), and triglycerides (-15.7% vs. 5.9%) in APA and CON groups after 12-week exercise intervention (P < 0.05). In contrast, a significant increase was found in HDL (7.7% vs. -0.6%) and VO2peak (4.83% vs. -1.6%) (P < 0.05). There were significant between-group differences in all measured variables, except for BMI. Conclusions: After-school physical activity effectively improved the endothelial dysfunction and lipid profile of adolescents with overweight/obesity. Therefore, based on the positive effects of these physical activities performed out of school, further use of after-school physical activity programs is suggested.
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Valipoor et al. (2022) conducted an RCT in Overweight/obesity (n=24). After-school physical activity (APA) vs. Control (no exercise intervention) was evaluated on C-reactive protein (CRP) percentage change (p=0.001). A 12-week after-school physical activity program significantly reduced C-reactive protein by 27.7% and improved lipid profiles and VO2peak in male children with overweight or obesity.
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