Key result
The Kattan postoperative radical prostatectomy nomogram was predictive of biochemical failure-free survival and treatment failure-free survival at 5 and 10 years.
Why the study?
Does the Kattan postoperative radical prostatectomy nomogram accurately predict biochemical failure-free survival and treatment failure-free survival in patients who underwent radical prostatectomy?
Cohort (n=1,931)
No
Does the Kattan postoperative radical prostatectomy nomogram accurately predict biochemical failure-free survival and treatment failure-free survival in patients who underwent radical prostatectomy?
The Kattan BCRFP nomogram remains a robust predictor of NCCN-defined biochemical failure in contemporary patients undergoing radical prostatectomy.
Answers are grounded in this paper and cite their sources.
Supports nomogram for post-RP counseling; extends validation to contemporary patients but leaves open prospective confirmation.
BACKGROUND: The Kattan postoperative radical prostatectomy (RP) nomogram is used to predict biochemical recurrence-free progression (BCRFP) after RP. However, external validation among contemporary patients using modern outcome definitions is limited. METHODS: A total of 1,931 patients who underwent RP at Roswell Park Cancer Institute (RPCI) between 1993 and 2014 (median follow-up, 47 months; range, 0-244 months) were assessed for NCCN-defined biochemical failure (BF) and RPCI-defined treatment failure (TF). Actual rates of biochemical failure-free survival (BFS; defined as 1 - BF) and treatment failure-free survival (TFS; defined as 1 - TF) were compared with Kattan BCRFP nomogram predictions. RESULTS: The Kattan BCRFP nomogram predictions at 5 and 10 years were predictive of BFS (area under the receiver operating characteristic curve [AUC], 0.772) and TFS (AUC, 0.774). The Kattan BCRFP nomogram tended to underestimate BFS and TFS compared with actual outcomes. The Kattan 5-year BCRFP predictions consistently overestimated actual 5-year BFS outcomes among subgroups of high- and intermediate-risk patients with at least 5-year outcomes. CONCLUSIONS: The Kattan BCRFP nomogram is a robust predictor of NCCN-defined BF in a large sample of patients with RP with substantial follow-up and modern, standardized failure definitions.
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Ondracek et al. (2016) conducted a cohort in Prostate Cancer (n=1,931). Kattan postoperative radical prostatectomy nomogram vs. Actual clinical outcomes was evaluated on Biochemical failure-free survival (BFS) and treatment failure-free survival (TFS) at 5 and 10 years (AUC 0.772 for BFS; AUC 0.774 for TFS). The Kattan postoperative radical prostatectomy nomogram was predictive of biochemical failure-free survival and treatment failure-free survival at 5 and 10 years.
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