August 1, 2002Journal of Clinical Oncology
International Validation of a Preoperative Nomogram for Prostate Cancer Recurrence After Radical Prostatectomy
Why the study?
Does a preoperative nomogram accurately predict 5-year freedom from recurrence in patients with prostate cancer after radical prostatectomy?
Population
6,232 patients with prostate cancer undergoing radical prostatectomy from seven different institutions…
Comparison
Preoperative nomogram predicting 5-year freedom… vs Actual follow-up observations
Design
Cohort
Follow-up
60 months
Authors
Discussion
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Member takes
Implication
Supports nomogram for preoperative counseling across institutions; extends multinational validation but leaves prospective outcome impact open.
Structured PICO
Does a preoperative nomogram accurately predict 5-year freedom from recurrence in patients with prostate cancer after radical prostatectomy?
P
Population
6,232 patients with prostate cancer undergoing radical prostatectomy from seven different institutions spanning three continents
I
Intervention
Preoperative nomogram predicting 5-year freedom from recurrence
C
Comparator
Actual follow-up observations
O
Outcome
Predictive accuracy of the nomogram for 60-month freedom from recurrence (measured by AUC and comparison of risk quadrants with Kaplan-Meier plots)
The preoperative nomogram accurately predicts 5-year freedom from recurrence across diverse international patient populations undergoing radical prostatectomy.
Cite This Study
Graefen et al. (2002) studied this question.