Key result
Quantitative flow ratio is a validated angiography-derived index for estimating the functional significance of coronary stenoses without the need for wire-based interrogation.
Why the study?
Coronary wire-based functional evaluation has not become routine in catheterization laboratories partly due to the need to advance a wire, prompting the development of angiography-derived indexes like quantitative flow ratio.
Quantitative flow ratio (QFR) is an emerging angiography-derived index for the physiological evaluation of coronary artery disease without requiring a pressure wire.
QFR may enable wire-free physiologic assessment; leaves open outcome impact and integration into practice.
The functional evaluation of coronary stenoses has obtained important clinical results in recent years, resulting in strong guideline recommendations. Nonetheless, the use of coronary wire-based functional evaluation has not yet become part of the routine in catheterization laboratories for several reasons, including the need to advance a wire into the coronary vessel to interrogate the stenosis. Angiography-derived indexes have been introduced to expand the current use of physiology to estimate the functional meaning of a stenosis on the basis of angiographic data only. The most studied and validated angiography-derived index is certainly the quantitative flow ratio. This article will summarize the basics of the quantitative flow ratio, the related validation studies and its current and future applications.
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Cerrato et al. (2021) conducted a review in Coronary Artery Disease. Quantitative flow ratio was evaluated. Quantitative flow ratio is a validated angiography-derived index for estimating the functional significance of coronary stenoses without the need for wire-based interrogation.
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