Key result
Baseline homocysteine levels ≥ 15 mmol/L were associated with a higher rate of non-culprit coronary lesion progression compared to levels < 15 mmol/L (32.3% vs. 14.6%, P=0.002).
Why the study?
Are elevated baseline homocysteine levels associated with the progression of non-culprit coronary lesions in elderly ACS patients after percutaneous coronary intervention?
Cohort (n=223)
Are elevated baseline homocysteine levels associated with the progression of non-culprit coronary lesions in elderly ACS patients after percutaneous coronary intervention?
Hazard Ratio: 1.024 (95% CI 1.007–1.042)
Absolute Event Rate: 32.3% vs 14.6%
p-value: p=0.007
Elevated baseline homocysteine levels (≥ 15 mmol/L) are independently associated with the angiographic progression of non-culprit coronary lesions in elderly ACS patients following PCI.
May aid risk stratification for NCCL progression in elderly ACS post-PCI; hypothesis-generating and requires prospective confirmation.
BACKGROUND: The influence of homocysteine (Hcy) on the migration and proliferation of vascular smooth muscle cells has been well established. However, the impact of Hcy levels on the progression of non-culprit coronary lesions (NCCLs) is controversial. This study aims to evaluate whether the plasma level of Hcy is related to the progression of NCCLs after percutaneous coronary stent implantation in elderly patients with acute coronary syndrome (ACS). METHODS: A total of 223 elderly patients (≥ 65 years old) with ACS undergoing stent implantation and follow-up coronary angiography were enrolled. Laboratory determination comprised of blood sample evaluation for Hcy was carried out before baseline coronary intervention. The patients were classified into two groups according to the blood Hcy tertiles (≥ 15 mmol/L or < 15 mmol/L). Patients were followed up for 12.2 months. NCCL progression was assessed by three-dimensional quantitative coronary angiography. RESULTS: A significantly higher ratio of NCCL progression was observed in the group with baseline Hcy concentrations above 15 mmol/L compared to the group with concentrations below 15 mmol/L (41/127, 32.3% vs. 14/96, 14.6%, P = 0.002). Multivariate Cox regression analysis showed that Hcy and diabetes mellitus were independent risk factors for NCCL progression. The crude hazard ratio (HR) of NCCL progression for Hcy level was 1.056 (95% CI: 1.01-1.104, P = 0.015). The adjusted HR of NCCL progression for Hcy level was 1.024 (95% CI: 1.007-1.042, P = 0.007). The adjusted HR of NCCL progression for diabetes mellitus was 1.992 (95% CI: 1.15-3.44, P = 0.013). CONCLUSIONS: Hcy is an independent risk factor for NCCL progression after 12 months of follow-up in elderly patients with ACS who has undergone percutaneous coronary stenting.
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Han et al. (2016) conducted a cohort in Acute coronary syndrome (n=223). Homocysteine ≥ 15 mmol/L vs. Homocysteine < 15 mmol/L was evaluated on Progression of non-culprit coronary lesions (NCCLs) (HR 1.024, 95% CI 1.007-1.042, p=0.007). Baseline homocysteine levels ≥ 15 mmol/L were associated with a higher rate of non-culprit coronary lesion progression compared to levels < 15 mmol/L (32.3% vs. 14.6%, P=0.002).
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