What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Post-Polio Syndrome (n=24). Intervention: Post-Polio Syndrome vs. Age-matched healthy controls. Primary outcome: Difference in Maximal Inspiratory Pressure (MIP) before and after Maximal Voluntary Ventilation (MVV) (p=0.001).

July 27, 2017PLoS ONEOpen Access

Comparison of activity and fatigue of the respiratory muscles and pulmonary characteristics between post-polio patients and controls: A pilot study

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Key result

Patients with Post-Polio Syndrome showed a deterioration in maximal inspiratory pressure following respiratory effort (-2.5 cmH2O) compared to an improvement in healthy controls (5.5 cmH2O).

Population

24 subjects: 12 patients with Post-Polio Syndrome able to walk for 6 minutes without human assistance and 12…

Design

Cross-sectional

Authors

DSDavid ShoseyovHebrew University of Jerusalem TCTali Cohen-KaufmanTel Aviv University ISIsabella SchwartzHebrew University of Jerusalem

Discussion

Member takes

Implication

MIP decline after effort may flag early fatigue in PPS; hypothesis-generating and requires prospective validation before clinical adoption.

Study Design

Type

Cross-Sectional (n=24)

Multicenter

Structured PICO

Population

24 adults (mean age 62 years, 58% female), including 12 with Post-Polio Syndrome able to walk for 6 minutes and 12 age-matched healthy controls, evaluated for respiratory muscle fatigue.

Comparator

Age-matched controls with no history of polio or pulmonary dysfunction

Outcome

Pulmonary function measures (FEV1, VC, SVC, RV, TLC, TGV), maximal respiratory pressure (MIP, MEP), and fatigue of respiratory muscles (sEMG during MVV)surrogate

Main Result

Absolute Event Rate: -2.5% vs 5.5%

p-value: p=0.001

Maximal respiratory pressure tests and sEMG measurements during maximal voluntary ventilation can identify early respiratory muscle fatigue in patients with Post-Polio Syndrome.

Limitations

The protocol for inducing respiratory muscle effort via MVV maneuvers might have been too short to induce fatigue in the healthy group.
The small sample size does not necessarily represent the entire PPS population.
Low MVV values were not set as exclusion criteria for the controls.
Small sample size
Protocol for inducing respiratory muscle effort via MVV maneuvers might have been too short to induce fatigue in the healthy group
Low MVV values were not set as exclusion criteria for the controls

Cite This Study

Shoseyov et al. (2017) conducted a cross-sectional in Post-Polio Syndrome (n=24). Post-Polio Syndrome vs. Age-matched healthy controls was evaluated on Difference in Maximal Inspiratory Pressure (MIP) before and after Maximal Voluntary Ventilation (MVV) (p=0.001). Patients with Post-Polio Syndrome showed a deterioration in maximal inspiratory pressure following respiratory effort (-2.5 cmH2O) compared to an improvement in healthy controls (5.5 cmH2O).

synapsesocial.com/papers/6a20d2a634bef10fdaeb075a https://doi.org/10.1371/journal.pone.0182036

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Implication

MIP decline after effort may flag early fatigue in PPS; hypothesis-generating and requires prospective validation before clinical adoption.

Comparison of activity and fatigue of the respiratory muscles and pulmonary characteristics between post-polio patients and controls: A pilot study

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Comparison of activity and fatigue of the respiratory muscles and pulmonary characteristics between post-polio patients and controls: A pilot study

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Also Consider