Key result
Sex differences exist in the incidence of NAFLD and the prevalence of metabolic disorders, confirming the relevance of developing sex-specific guidelines for personalized treatment.
Why the study?
Sex differences exist in the incidence of NAFLD and prevalence of metabolic disorders, motivating a summary of current knowledge on epidemiology, pathogenesis, and the role of sex hormones.
This review emphasizes the importance of considering sex differences and hormonal status, including the impact of PCOS, in the personalized management of patients with non-alcoholic fatty liver disease.
May inform sex-specific NAFLD approaches; leaves open prospective validation before guideline changes.
Non-alcoholic fatty liver disease (NAFLD) has become the most common cause of chronic liver disease worldwide. Growing evidence supports the concept of NAFLD as a multisystem disease associated with metabolic syndrome. Sex differences do exist in the incidence of NAFLD among the population as much as in the prevalence of certain metabolic disorders in patients with liver steatosis. This review summarizes the current knowledge on the epidemiology and pathogenesis of NAFLD, including the role of sex hormones in the development of hepatic steatosis. We discuss the main metabolic disorders in patients with NAFLD and the potential mechanisms of their interaction with the hormonal state. The impact of polycystic ovary syndrome on NAFLD progression is also considered. The results of the conducted analysis of literature data confirms the relevance of developing sex-specific guidelines for identifying metabolic disorders in patients with NAFLD and recommendations for personalized treatment.
No takes yet. Share an insight, caveat, or question.
Shaabani et al. (2020) conducted a review in Non-alcoholic fatty liver disease (NAFLD). Sex differences and hormonal status was evaluated. Sex differences exist in the incidence of NAFLD and the prevalence of metabolic disorders, confirming the relevance of developing sex-specific guidelines for personalized treatment.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: